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Robatumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IGF1 Receptor Therapeutic Antibody TAB-209 1mg Please Inquiry
Product Detail
Cat
TAB-209
Product Overview
Recombinant monoclonal antibody to IGF1 Receptor. Robatumumab (proposed INN) is a monoclonal antibody and an antineoplastic by Schering-Plough. It binds to CD221, the insulin-like growth factor 1 receptor.
Target
IGF1 Receptor
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
CAS
934235-44-6
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens insulin-like growth factor I receptor (IGF-1R, CD221)], Homo sapiens monoclonal antibody; gamma1 heavy chain (1-448) [Homo sapiens VH (IGHV3-48*03 (87.80%) -(IGHD)-IGHJ6*01) [8.7.12] (1-118) -IGHG1*01 (119-448)], (221-214")-disulfide with kappa light chain (1"-214") [Homo sapiensV-KAPPA (IGKV3-20*01 (83.30%) -IGKJ1*01) [6.3.9] (1"-107") -IGKC*01] (108"-214"); (227-227"":230-230"")-bisdisulfide dimer
Predicted N terminal
H chain: EVQLVQS; L chain: EIVLTQS
Molecular Weight
144600
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
Function
ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleo
Gene ID
3480
Synonyms
IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
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