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Omalizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IGHE Therapeutic Antibody (omalizumab) TAB-007 1mg Please Inquiry
Product Detail
Cat
TAB-007
Product Overview
Recombinant monoclonal antibody to Human IgE. Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. While allergy occurs more frequently in individuals with higher serum IgE levels, such a correlation is only statistical and not absolute. Some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems.
Target
IgE
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
CAS
242138-07-4
Trade name
omalizumab
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1,anti-(human immunoglobulin E Fc region) (human-mouse monoclonal E25 clone gamma-chain), disulfide with human-mouse monoclonal E25 clone kappa-chain, dimer
Predicted N terminal
H chain: EVQLVESL chain: DIQLTQS
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
IgE is a member of the immunoglobulin family that mediates allergic responses such as asthma, food allergies, type 1 hypersensitivity and the familiar sinus inflammation suffered on a widespread basis. IgE is secreted by, and expressed on the surface of, B-cells.
Gene ID
28223
Synonyms
IGHE; Immunoglobulin heavy constant epsilon;
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