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Gevokizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL1 beta Therapeutic Antibody TAB-161 1mg Please Inquiry
Product Detail
Cat
TAB-161
Product Overview
Recombinant monoclonal antibody to IL1 beta. Gevokizumab is a humanized monoclonal antibody used in the treatment of diabetes and inflammatory disorders.
Target
IL1 beta
Type
IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CAS
1129435-60-4
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G2-kappa, anti-[Homo sapiens IL1B (interleukin 1 beta, 1L1F2, IL-1B)], humanized monoclonal antibody
Predicted N terminal
H chain: QVQLQES; L chain: DIQMTQS
Molecular Weight
145200
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaggedlandin and collagenase from synovial cells.
Function
cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding;
Gene ID
3553
Synonyms
IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA;
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