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Rovelizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ITGB2 Therapeutic Antibody (LeukArrest) TAB-044 1mg Please Inquiry
Product Detail
Cat
TAB-044
Product Overview
Recombinant monoclonal antibody to CD18. Rovelizumab, also known as LeukArrest and Hu23F2G, is a humanized monoclonal antibody which was an experimental immunosuppressive drug. The drug is a monoclonal antibody that suppresses white blood cells which become overly active during shock.
Target
ITGB2
Type
IgG4
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, IHC and most other immunological methods.
CAS
197099-66-4
Trade name
leukarrest
Specificity
Tested positive against native human antigen.
Protein Construction
ImmunoglobulinG4, anti-(human CD11 (antigen)/integrin b2) (human-mousemonoclonal Hu23F2G g4-chain), disulfide with human-mouse monoclonal Hu23F2G k-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DIQMTQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Function
binding; glycoprotein binding; protein kinase binding; receptor activity;
Gene ID
3689
Synonyms
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); CD18, integrin, beta 2 (antigen CD18 (p95), lymphocyte function associated antigen 1; macrophage antigen 1 (mac 1) beta subunit) , MFI7; integrin beta-2; LFA 1; MAC 1; integrin beta chain, beta 2; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1;
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