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Placulumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNF Therapeutic Antibody TAB-254 1mg Please Inquiry
Product Detail
Cat
TAB-254
Product Overview
Recombinant monoclonal antibody to TNF. Placulumab is a human monoclonal antibody designed for the treatment of inflammatory diseases
Target
TNF
Type
[V-kappa]2 - Fc
Immunogen
Full length native protein (purified) (Human).
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
CAS
945781-29-3
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin (V-kappa)2-Fc gamma1, anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamily member 2, TNFSF2, TNFalpha, TNFA)], Homo sapiens monoclonal antibody
Predicted N terminal
H chain: DIQMTQS
Molecular Weight
78700
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Function
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;
Gene ID
7124
Synonyms
TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha;
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