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denosumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human TNFSF11 Therapeutic Antibody (XGEVA) TAB-H18 1mg Please Inquiry
Product Detail
Cat
TAB-H18
Product Overview
Recombinant human antibody to Human TNFSF11. Denosumab is a fully human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, bone metastases, multiple myeloma, and giant cell tumor of bone. Denosumab is designed to inhibit RANKL (RANK ligand), a protein that acts as the primary signal for bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defenses against bone destruction.
Type
IgG2
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
615258-40-7
Trade name
xgeva
Specificity
TNFSF11 (tumor necrosis factor (TNF) superfamily member 11, osteoclast differentiation factor, ODF, OPGL, RANKL, TRANCE, CD254) [Homo sapiens]
Protein Construction
Prolia is brand name for osteoporosis, Xgeva is brand name for cancer.immunoglobulin G2, anti-(human tumor necrosis factor ligand superfamily member 11 (human osteoclast differentiation factor)) (humanmonoclonal AMG162 heavy chain), disulfide with human monoclonal AMG162 light chain, dimer
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Background
Antigen Description
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.
Function
cytokine activity; cytokine activity; receptor activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding;
Gene ID
8600
Synonyms
TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; sOdf; OPTB2; hRANKL2;
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