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Felvizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-RSV Therapeutic Antibody TAB-098 1mg Please Inquiry
Product Detail
Cat
TAB-098
Product Overview
Recombinant monoclonal antibody to respiratory syncytial virus. Felvizumab is a humanized monoclonal antibody against respiratory syncytial virus.
Target
respiratory syncytial virus
Type
IgG1 - kappa
Immunogen
Recombinant FP
Species Reactivity
RSV
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
167747-20-8
Specificity
Tested positive against native RSV antigen
Protein Construction
Immunoglobulin G1,anti-(respiratory syncytial virus) (human-mouse monoclonal g1-chain), disulfide withhuman-mouse monoclonal k-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DIQMTQS
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
Monoclonal Antibody binds to the fusion glycoprotein of RSV. Against respiratory syncytial virus.
Antigen Description
Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein is a Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (protein F) interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between host cell and virion membranes. Notably, RSV fusion protein is able to interact directly with heparan sulfate and therefore actively participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
Keywords
RSV Fusion F Glycoprotein; RSV; Respiratory Syncytial Virus
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