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Pritoxaximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Shiga toxin 1 B subunit Therapeutic Antibody TAB-896 1mg Please Inquiry
Product Detail
Cat
TAB-896
Target
Shiga toxin 1 B subunit
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
E. coli
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, IHC and most other immunological methods.
CAS
1351470-16-0
Predicted N terminal
QVQLQESG
Molecular Weight
Approximately 150 kDa
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Introduction
Shiga toxins act to inhibit protein synthesis within target cells. The toxin has two subunits designated A and B. The B subunit is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide (Gb3).
Antigen Description
Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages. The toxin has two subunits—designated A(mol. wt. 32000 D) and B(mol. wt. 7700 D)—and is one of the AB5 toxins. The B subunit is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide (Gb3). Following this, the A subunit is internalised and cleaved into two parts. The A1 component then binds to the ribosome, disrupting protein synthesis.
Keywords
Shiga toxin 1 B subunit; Shiga toxins
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