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Chimeric Antigen Receptor (CAR) Products

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Creative Biolabs offers a wide selection range of Chimeric Antigen Receptor (CAR) construct products targeting many different tumor associated antigens respectively. Meanwhile, our elite CAR construction products, such as lentivirus and retrovirus particles, have the best performance in both research and industry field. As the first-in-class biotech developer and provider, scientists of Creative Biolabs focus on applying outstanding technologies to the discovery and development of potential therapeutic approaches, such as custom CARs construction services. Besides the service of CAR construction, expression and purification, we also provide Quality Controls Measures which guarantee the CAR construction products with the highest quality and outstanding performance.

Chimeric antigen receptors (CARs) are composed of an extracellular antigen binding domain [usually a single-chain variable fragment (scFv) derived from monoclonal antibody] linked to the transmembrane domain which is followed by cytoplasmic signaling domains. Upon binding to the scFv specific antigen, the genetically modified CAR-T cells carry out the effector functions, and subsequently trigger the cytotoxicity depended lysis of tumor cells. The effectiveness of the CAR immunotherapy has been proved in a variety of animal models, nowadays, many clinical trials (from first to third generation CARs) with CAR-based genetically engineered T lymphocytes for treating diverse cancers are ongoing. Creative Biolabs has established a unique unparalleled CAR construction and production platform, which has achieved significant contribution to the development of this powerful technology.

Associated malignancy Target antigen Receptor type CARs generation
Leukemia CD19 ScFv-CD28-41BB-CD3ζ Third
CD19 ScFv-CD28 Second
CD19 ScFv-41BB-CD3ζ  Second
k-light chain ScFv-CD3ζ (VZV) First
CD33 ScFv-CD28-CD3ζ Second
CD33 ScFv-41BB-CD3ζ Second
CD123 ScFv-CD28-CD3ζ Second
WT1 ScFv-41BB-CD3ζ Second
Pr3 ScFv-41BB-CD3ζ Second
Lymphoma CD20 ScFv-CD28-CD3ζ Second
CD19 ScFv-CD28-41BB-CD3ζ Third
CD22 ScFv-CD28-CD3ζ Second
k-light chain ScFv-CD3ζ (VZV) First
CD19 ScFv-b2c-CD3ζ Second
CD19 ScFv -CD3ζ First
CD19 ScFv-41BB-CD3ζ Second
CD30 ScFv-CD28-CD3ζ Second
Breast and others erb-B2 ScFv-CD28mut-CD3ζ Second
erb-B2 ScFv-CD28-OX40-CD3ζ Third
erb-B 2,3,4 ScFv-CD3ζ First
MUC1 ScFv-FcεRIγ First
LeY ScFv-CD3ξ First
Prostate cancer erb-B2 ScFv-CD3ζ First
PSCA scFv-FcεRIγ First
Colorectal cancer EGP-40 ScFv-CD28-CD3ζ vs. CD3ζ Second
erb-B2 ScFV-CD28-FcεRIγ Second
Lung malignancy Her2/neu ScFv-CD3ζ First
Adenocarcinomas TAG-72 ScFv-FcεRIγ (alloantigen) First
Cervical carcinoma CD44v7/8 ScFv-CD28-CD3ζ Second
Melanoma GD3 ScFv-CD3ζ First
MAGE-A1 ScFv-CD4-CD3ζ Second
Renal cell carcinoma CAIX ScFv-CD3ζ(EBV) First
Epithelial derived tumors LeY ScFv-CD3ξ First
Advanced osteosarcoma< Her2/neu scFv-CD3ζ First
Rhabdomyosarcoma Fetal acethylcholine receptor ScFv-CD3ζ First
Ewing’s GD2 ScFv-CD3ζ First
sarcoma NKG2D ScFv-CD28-CD3ζ Second
MUC1 ScFv-4-1BB-CD3ζ Second
survivin ScFv-CD28-4-1BB-CD3ζ Third
CSPG4 ScFv-CD28-4-1BB-CD3ζ Third
Medulloblastoma Her2/neu ScFv-CD3ζ First
IL-13R-a2 ScFv-CD3ζ (Influenza MP-1) First
Neuroblastoma GD2 ScFv-CD3ζ First
GD2 ScFv-iC9-GD2-CD28-OX40 Third
L1 cell adhesion molecule ScFv-CD3ξ First
CD171 ScFv-CD28-4-1BB-CD3ζ Third
EGFRvIII ScFv-CD28-4-1BB-CD3ζ Third
ROR1 ScFv-CD28-4-1BB-CD3ζ Third
Ovarian cancer α-Folate receptor ScFv-CD28/4-1BB-CD3ζ Second
FBP ScFv-CD3ζ First
MUC1 ScFv-FcεRIγ First
Glioma Her2/neu scFv-CD3ζ First
IL-13R-a2 ScFv-CD3ζ (EBV) First
Multiple malignancies EGP-2 ScFv-CD28-CD3ζ (Influenza) Second
EGP-2 ScFv-CD28-CD3ζ Second
Various tumors Mesothelin ScFV-CD4-FcεRIγ Second
Mesothelin ScFv-CD8-CD3ζ Second
Mesothelin ScFv-FceRIγ First
NKG2D ligands ScFv-FcεRIγ First
Tumor neovasculature KDR ScFV-CD3ζ (vaccination) First
VEGF-R2 ScFv-FcεRIγCAIX First
Prostate/tumor vasculature PSMA ScFv-FcεRIγ First
Virus (CMV or EBV or adenovirus) CD28 ScFv-FcεRIγ First

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