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Anti-TcdA Single Domain Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-C. difficile TcdA Single Domain Antibody NAB-LXY0008 1mg Please Inquiry
Product Detail
Cat
NAB-LXY0008
Target
TcdA
Type
llama VHH
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
C. difficile
Expression Host
E.coli
Specificity
Tested positive against native human antigen.
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
Clostridium difficile toxin A (TcdA) is a toxin generated by Clostridium difficile. It is similar to Clostridium difficile Toxin B. The toxins are the main virulence factors produced by the gram positive, anaerobic, Clostridium difficile bacteria. The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis.

TcdA is one of the largest bacterial toxins known. With a molecular mass of 308kDa, it is usually described as a potent enterotoxin, but it also has some activity as a cytotoxin. The toxin acts by modifying host cell GTPase proteins by glucosylation, leading to changes in cellular activities. Risk factors for C. difficile infection include antibiotic treatment, which can disrupt normal intestinal microbiota and lead to colonization of C. difficile bacteria.
Gene ID
4914076
Synonyms
tcdA; toxA; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium difficile Toxin A
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