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Anti-APP Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human APP Antibody Fab Fragment MOM-18226-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18226-F(E)
Product Overview
Recombinant Humanized (from mouse) Antibody Fab Fragment is bind to Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
Target
Abeta
Type
Fab Fragment based on Humanized (from mouse) IgG4 - kappa
Immunogen
Pegylated beta-Amyloid Peptide
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Predicted N terminal
H chain: EVQLVES; L Chain: DIVMTQS
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
At -20°C for one year.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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