|Recombinant Anti-Human APP Antibody
- Product Overview
- Recombinant Humanized (from mouse) Antibody is specific to Human Abeta, expressed in Chinese Hamster Ovary cells(CHO)
- Humanized (from mouse) IgG2 - kappa
- The details of the immunogen for this antibody are not available.
- Species Reactivity
- Expression Host
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- Tested positive against native antigen.
- Protein Construction
- Immunoglobulin G2, anti-(human beta-amyloid) (human-mouse monoclonal PF-04360365 clone 9TL heavy chain), disulfide with human-mouse monoclonal PF-04360365 clone 9TL light chain, dimer
- Predicted N terminal
- H chain: QVQLVQS; L Chain: DVVMTQS
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
- Antigen Description
- Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
- DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; transition metal ion binding;
- Gene ID
- APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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