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Anti-IGF1R Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human IGF1R Antibody MOM-18078 1mg Please Inquiry
Product Detail
Cat
MOM-18078
Product Overview
Recombinant Human Antibody specifically binds to Human IGF1 Receptor, expressed in Chinese Hamster Ovary cells(CHO)
Target
IGF1 Receptor
Type
Human IgG1 - lambda
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
Specificity
Tested positive against native antigen.
Protein Construction
Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human monoclonal IMC-A12 γ-chain), disulfide with human monoclonal IMC-A12 lambda-chain, dimer
Predicted N terminal
H Chain: EVQLVQS; L Chain: SSELTQD
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
Function
ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein tyrosine kinase activity; receptor activity;
Gene ID
3480
Synonyms
IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
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