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Anti-lpa Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human lpa Antibody Fab Fragment MOM-18426-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18426-F(P)
Product Overview
Recombinant Mouse Antibody Fab Fragment is against Human LPA, expressed in E. coli
Target
LPA
Type
Fab
Immunogen
Recombinant Human Lipoprotein a (P08519).
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis.
Function
apolipoprotein binding; endopeptidase inhibitor activity; fibronectin binding; heparin binding; peptidase activity; serine-type endopeptidase activity;
Gene ID
4018
Synonyms
LPA; lipoprotein, Lp(a); LP; apolipoprotein(a); lp(a); apo(a); antiangiogenic AK38 protein; AK38; APOA
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