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Anti-notch2 Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human notch2 Antibody Fab Fragment MOM-18449-F(P) 1mg Please Inquiry
Product Detail
Cat
MOM-18449-F(P)
Product Overview
Recombinant Mouse Antibody Fab Fragment is specific to Human NOTCH2, expressed in E. coli
Target
NOTCH2
Type
Fab
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
Function
calcium ion binding; protein binding; receptor activity;
Gene ID
4853
Synonyms
NOTCH2; notch 2; Notch (Drosophila) homolog 2 , Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Notch homolog 2; hN2; AGS2; HJCYS
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