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Anti-notch2 Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human notch2 Antibody MOM-18449 1mg Please Inquiry
Product Detail
Cat
MOM-18449
Product Overview
Recombinant Mouse Antibody binds selectively to Human NOTCH2, expressed in Chinese Hamster Ovary cells(CHO)
Target
NOTCH2
Type
IgG
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
Function
calcium ion binding; protein binding; receptor activity;
Gene ID
4853
Synonyms
NOTCH2; notch 2; Notch (Drosophila) homolog 2 , Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Notch homolog 2; hN2; AGS2; HJCYS
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