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Anti-tfrc Antibody Fab

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human tfrc Antibody Fab Fragment MOM-18319-F(E) 1mg Please Inquiry
Product Detail
Cat
MOM-18319-F(E)
Product Overview
Recombinant Mouse Antibody Fab Fragment is directed against Human TFRC, expressed in Chinese Hamster Ovary cells(CHO)
Target
TFRC
Type
Fab
Immunogen
Tissue / cell preparation (Human). (KG1 acute myelogenous leukaemia cell line).
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Function
Hsp70 protein binding; chaperone binding; peptidase activity; receptor activity; transferrin receptor activity;
Gene ID
7037
Synonyms
TFRC; transferrin receptor (p90, CD71); transferrin receptor protein 1; CD71; TFR1; T9; TR; TFR; p90; TRFR
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