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Anti-tfrc Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human tfrc Antibody MOM-18501 1mg Please Inquiry
Product Detail
Cat
MOM-18501
Product Overview
Recombinant Mouse Antibody is specific to Human TFRC, expressed in Chinese Hamster Ovary cells(CHO)
Target
TFRC
Type
IgG
Immunogen
Pre-B cell line NALM-6.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>95.0% as determined by analysis by RP-HPLC.
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Function
Hsp70 protein binding; chaperone binding; peptidase activity; receptor activity; transferrin receptor activity;
Gene ID
7037
Synonyms
TFRC; transferrin receptor (p90, CD71); transferrin receptor protein 1; CD71; TFR1; T9; TR; TFR; p90; TRFR
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