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Anti-unc5b Antibody

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human unc5b Antibody MOM-18629 1mg Please Inquiry
Product Detail
Cat
MOM-18629
Product Overview
Recombinant Mouse Antibody is against Human UNC5B, expressed in Chinese Hamster Ovary cells(CHO)
Target
UNC5B
Type
IgG
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
Specificity
Tested positive against native antigen.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Function
netrin receptor activity; protein binding; receptor activity;
Gene ID
219699
Synonyms
UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2; unc-5 homolog 2; protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; p53-regulated receptor for death and life protein 1;
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