Creative Biolabs develops and commercializes a full range of integrated innovative services that are based on phage display technology. We have ...
Creative Biolabs can offer advanced protein engineering platform for your specific project, including high-scale expression, crystallization and characterization...
Creative Biolabs has established custom membrane protein and membrane protein antibody production platforms for antibody discovery...
Creative Biolabs provides a full range of services based on our matured hybridoma platform. Our featured services involve the custom monoclonal antibody production, from ...
Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies, Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence that no longer has the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology.
Advantages of PEGylation
PEGylation is an established tool to increase potency, half-life and solubility of biopharmaceuticals, which can be used for modifying biological compounds such as cytokines, antibody fragments, interleukins, hormones, oligonucleotides and some of proteins and peptides.
PEGylation can be effective in:
• Improving Bioavailability
• Prolonging Blood Circulation
• Maximizing Pharmacokinetics
• Reducing Immunogenicity
• Decreasing Frequency of Dosing
Creative Biolabs provides high-performance activated PEGs for PEGylated drugs from early development stage to commercial use. We have many years of experience in manufacturing high quality methoxy polyethylene glycol, a key starting material of activated PEG in the pharmaceutical field. Our activated PEGs have a narrow polydispersity and a low diol content with a wide range of molecular weight, ranging from 2kDa to 80kDa.
Our customized PEGylation services include:
• Exploration and establishment of PEGylation process
• Process development and optimization for the production of PEGylated drugs
• Development of analytical methods for PEGylated drugs
• Production of proof of concept materials
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us