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Magic™ Membrane Protein Human IL21R (Interleukin 21 receptor) Expressed in NS0 for Antibody Discovery, Partial (20-236aa) (CAT#: MPX0248K)

Datasheet
This product is a 51.7 kDa Human IL21R membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL21R
  • Protein Length
  • Partial (20-236aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 51.7 kDa
  • TMD
  • 1
  • Sequence
  • CPDLVCYTDYLQTVICILEMWNLHPSTLTLT
    WQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITD
    QSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYML
    KGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQV
    RAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • IL21R
  • Full Name
  • Interleukin 21 receptor
  • Introduction
  • The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
  • Alternative Names
  • IL21R; NILR; CD360; IMD56; interleukin-21 receptor; IL-21 receptor; novel interleukin receptor; Interleukin 21 receptor

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