Magic™ Membrane Protein Mouse Kcnj1 (Potassium inwardly-rectifying channel, subfamily J, member 1) (CAT#: MP0019F)

Datasheet

Protein-ATP-sensitive inward rectifier potassium channel plays, in the kidney, a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

Product Specifications

Host Species
Mouse

Target Protein
Kcnj1

Protein Length
Full Length

Protein Class
Channel

Molecular Weight
42.7 kDa

Sequence
MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRY
KMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQ
VTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAV
ISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNEN
LFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEV
LWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFV
LSEVDETDDTQM

Product Description

Activity
To be tested

Application
Screening & display technologies, Structural biology

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>40% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
Kcnj1

Full Name
Potassium inwardly-rectifying channel, subfamily J, member 1

Introduction
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity).

Alternative Names
ROMK, Romk2, Kir1.1

Gene ID
56379

UniProt ID
O88335

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