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NativeExtract™ Human GPR153 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX240)

Datasheet
This product is recombinant Human GPR153 protein in native nanodisc form. The synthetic compound we developed can solubilize the GPR153 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GPR153
  • Protein Length
  • Full length
  • Molecular Weight
  • 65.4kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GPR153
  • Full Name
  • G protein-coupled receptor 153
  • Introduction
  • This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells.
  • Alternative Names
  • PGR1; probable G-protein coupled receptor 153; G-protein coupled receptor PGR1; GPR153; G protein-coupled receptor 153

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