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NativeExtract™ Human HRH1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX183)

Datasheet
This product is recombinant Human HRH1 protein in native nanodisc form. The synthetic compound we developed can solubilize the HRH1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HRH1
  • Protein Length
  • Full length
  • Molecular Weight
  • 55.8kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • HRH1
  • Full Name
  • Histamine receptor H1
  • Introduction
  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Alternative Names
  • H1R; H1-R; HH1R; hisH1; histamine H1 receptor; histamine receptor, subclass H1; HRH1; Histamine receptor H1

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