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NativeExtract™ Human HTR2B Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX346)

Datasheet
This product is recombinant Human HTR2B protein in native nanodisc form. The synthetic compound we developed can solubilize the HTR2B protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HTR2B
  • Protein Length
  • Full length
  • Molecular Weight
  • 54.3kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • HTR2B
  • Full Name
  • 5-hydroxytryptamine receptor 2B
  • Introduction
  • This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene.
  • Alternative Names
  • 5-HT2B; 5-HT-2B; 5-HT(2B); 5-HT 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; serotonin receptor 2B; HTR2B; 5-hydroxytryptamine receptor 2B

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