3D Spheroid Model for Immuno-Oncology Drug Discovery and Development

Traditional exploration in oncology and immunology has been hindered by poor clinical relevance and low throughput. Creative Biolabs is dedicated to revolutionizing the field of tumor immunology through the use of our advanced 3D spheroid model， which offers a unique opportunity to explore tumor heterogeneity and tumor microenvironment dynamics.

Traditional Immuno-oncology Models

The 2D tumor cell culture, which is the mainstay of traditional research, only provides an incomplete simulation of the pathological processes in human tissues, lacking critical pathological information such as tumor heterogeneity, cellular interactions, microenvironment structure, and gene expression.

3D Tumor Spheroid Model

In comparison to traditional 3D in vitro approaches, 3D tumor spheroid models can accurately recapitulate critical aspects, such as the gradients of oxygen and nutrient infiltration, the presence of hypoxic and acidic core regions, the manifestation of appropriate aerobic glycolysis levels, and the exhibition of similar pathologies observed in a clinical environment.

Fig 1. Viral antigens are presented on the cell surface membrane within a tumor spheroid. Fig 1. 3D tumor spheroid construction.¹

Why Choose Creative Biolabs’ 3D Immuno-oncology Spheroid Model

To overcome obstacles in tumor immunology research, Creative Biolabs has introduced a 3D tumor spheroid model that is more suitable for clinical relevance studies or drug development, aiming to advance the field of immuno-oncology. By choosing us, you will benefit from:

Advanced oncology research

Our model can be combined with various studies, such as immune infiltration, chemotherapy, and immune checkpoint blockade, to predict more durable and specific patient responses.

Customizable TME characteristics

We can incorporate 3D tumor geometry, hypoxic core, and heterogeneous cell populations into our model, retaining the relevance of interaction within the cancer microenvironment.

Cell-cell interactions

Through combinations with immune cells, endothelial cells, or stromal cells, our model facilitates the study of tumor-stroma/immune interactions.

Endpoint analysis

The 3D spheroid can be combined with flow cytometry, immunofluorescence, or immunohistochemistry methods to provide you with insightful and accurate biomarker data.

Products Available

Our 3D spheroid model provides a sophisticated and highly relevant in vitro system that mimics the complexity of tumors and their microenvironment. We can build the mono-cultured spheroid model using isolated cells within the tumor or patient-derived progenitor cells, or additional physiological complexity to the model by combining it with stromal cells, endothelial cells, or immune cells. In addition, more complex cancer organoid mono-culture/co-culture models have also been developed. For more details, please click the links below.

Our Services

Our team of experienced scientists and technicians provides full technical support throughout the entirety of your research project. From study design and protocol optimization to data interpretation, we are committed to ensuring the success of your immuno-oncology initiatives. Don't miss out on the opportunity to unlock new possibilities in immuno-oncology – reach out to us now and let's collaborate towards a healthier future.

Reference

To, J.; et al. A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function. Commun Biol. 2021, 4(1): 56. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part(A), row 1-3, column 2-4.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Models

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