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Antibody Production by DNA Immunization

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Creative Biolabs is proud to offer the Magic™ DNA immunization service to produce custom polyclonal and monoclonal antibodies. The state-of-the-art technology is developed by outstanding research team, which includes a Nobel Laureate. As a highly optimized service, this technology enables the immunized hosts to produce interested antigens in vivo with in situ posttranscriptional modifications and then induce powerful immune responses.

DNA immunization is one of the most straight-forward approaches  to elicit an immune reaction against a foreign protein. Differ from the conventional immunization methods, DNA immunization permits in vivo antigen production, bypassing the time-consuming (sometimes also difficult) processes of immunogens (e.g. multi-pass membrane proteins) synthesis and purification. In addition, the expressed proteins can maximally maintain the native structures and go through appropriate posttranscriptional modifications which are valuable for the development of therapeutic antibodies which requires high affinity antibody that recognizes the native conformation of target antigen. Meanwhile, this approach is also an ideal solution to develop antibodies against membrane proteins or other challenging or problematic antigens, such as unknown proteins whose genes have been obtained, toxic proteins, insoluble proteins, unstable proteins, proteins containing disulfide bonds and large protein domains. Furthermore, DNA immunization has also been considered as an innovative tool in the early phases of DNA vaccine development.

Antibody Production by DNA Immunization

Creative Biolabs provides the unique Magic™ DNA immunization service for antibody development against difficult target. In general, current applied DNA immunization technologies, like gene gun and electroporation, result in low antibody titer and limited transfection efficiency. Magic™ DNA immunization is able to improve the transfection efficiency, expression level and also induce high level antibody response. Based on the provided sequencing information, our experienced scientists could offer one-stop service from gene synthesis and plasmid formulation to immunization, and then generate high quality polyclonal or monoclonal antibodies by one of our comprehensive antibody discovery platforms (e.g. phage display platform, Native™ antibody discovery platform and hybridoma platform). In addition, Creative Biolabs also provides the specific Magic™ transfection reagents which can achieve high efficiency transfection of either DNA, mRNA or siRNA for a wide range of cell types of cell lines to assist our clients’ research and project development.

Additional advantages of Magic™ DNA immunization system:

As a pioneer in the field of antibody research and development, Creative Biolabs has successfully applied service for thousands of antibody discovery projects. Either the interested antigen is a membrane protein or other challenging targets, our experienced scientists are confident in tailoring the most appropriate proposal to meet our customers’ specific requirements.

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