Category:
Non-Human Primate (NHP) related Antibody Products
CD95 Monoclonal Antibody (CM5R.1), FITC (NHP-AB105)
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Detailed Product Description
Technical Specifications
Product Property
Target Information
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This product is an antibody conjugated with FITC that was generated by immunizing mice against human CD95 transfected L cells. It is used only in in vitro assays.
Introduction:
CD95, also known as Fas and APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.
Conjugate:
FITC
Antibody Isotype:
IgG1
Applications:
Flow Cytometry
Host Species:
Mouse
Species Reactivity:
African green Monkey; Human
Immunogen:
Human CD95 transfected L cells
Format:
Liquid
Buffer:
Supplied in PBS/NaN3
Storage:
Store at 4⁰C.
Target:
CD95
Clone:
CM5R.1
Clonality:
Monoclonal
Alternative Names:
Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; Apo1 antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FASLG receptor; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
Entrez Gene ID:
355
- CD95 Monoclonal Antibody (CM5R.1), FITC (NHP-AB105) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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