GCLC Polyclonal Antibody (NHP-AB350)

• This product is an antibody that was generated by immunizing rabbit against amino acids 295 - 313 of GCLC (Rat). It is used only in in vitro assays.

Detailed Product Description

• Introduction: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
• Conjugate: None
• Applications: IHC; IP

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Monkey; Mouse; Rat
• Immunogen: Amino acids 295 - 313 of GCLC (Rat)

Product Property

• Purification: Protein A Column
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: gamma GCS-HS; Gamma-ECS; Gamma-glutamylcysteine synthetase; gamma-glutamylcysteine synthetase heavy subunit; GCS heavy chain; Glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase, catalytic subunit; Glutamylcysteine gamma synthetase light chain
• Entrez Gene ID: 2729