Category:
Non-Human Primate (NHP) related Antibody Products
TLR7 Polyclonal Antibody (NHP-AB474)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a portion of amino acids 900-950 of human TLR7. It is used only in in vitro assays.
Introduction:
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Conjugate:
None
Antibody Isotype:
IgG
Applications:
IHC; WB
Host Species:
Rabbit
Species Reactivity:
Chimpanzee; Human; Monkey
Immunogen:
A portion of amino acids 900-950 of human TLR7
Purification:
Protein G Column
Format:
Liquid
Concentration:
0.5 mg/mL
Buffer:
PBS, 0.2% gelatin, 0.05% sodium azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
RP23-139P21.3; Toll-like receptor 7; toll-like receptor 7-like
Entrez Gene ID:
51284
- TLR7 Polyclonal Antibody (NHP-AB474) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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