Immune sdAb Library Construction Service
Creative Biolabs has been long-term devoted to the development and application of single-domain antibody (sdAb). To meet the growing demands of sdAb, Creative Biolabs has established the best solutions to generate an immune sdAb library with our reliable and robust platform, brilliant technical scientists, and advanced techniques. Our scientists are confident in solving each customer’s specific problems and requirements.
Advantages of Immune sdAb Library
Successful enrichment of rare sdAb specificities or identification of antigen-specific sdAbs can be straightforward from an immune sdAb library made with the material of immunized donor. The generation of immune sdAb libraries stands out as a highly convenient option to easily generate specific binders because the immune specificity is not shuffled during the construction of the library. The high affinity of sdAb binders retrieved from the immune libraries are ensured based on in vivo somatic maturation. In general, the affinities of these sdAbs could be in low-nM or pM levels. Furthermore, libraries constructed from a small blood sample already represent the immune sdAb repertoire of lymphocytes presenting in the bloodstream of the immunized animals. In practical terms, it means that the size of sdAb libraries can be several orders smaller to reach a similar representation of the original immune repertoire.
Fig.1 Immune sdAb Library.
Immune sdAb Library at Creative Biolabs
High-affinity sdAb generation, especially from immune sdAb libraries, remains a highly valued tool for most biomedical applications, including disease diagnosis, bioimaging, drug screening, and targeting therapy. The possible selection to obtain antigen-specific sdAb benefits from the usage of our dedicated libraries from immunized animals that contain a high ratio of binder to non-binder clones due to the in vivo proliferation of B-cells carrying antigen-specific sdAbs.
Currently, Creative Biolabs offers a custom immune sdAb library construction service to guarantee the generation of the unique specificity and high affinity of sdAbs. The whole procedure at Creative Biolabs, from the first immunization to the construction of the immune sdAb library, is routinely performed in less than a few months. The use of our immune library is the fastest and more reliable way to obtain sdAbs with high affinities. With a full network of sdAb discovery and development, and experts using the most up-to-date technologies, we are your perfect sdAb development program partner around the world.
Creative Biolabs is a world leader in sdAb services, and our focus is to exceed your expectations while providing accurate and reliable sdAb-related services. With over ten years of experience, we are happy to help resolve any questions you may have about sdAb discovery and development, and our state-of-the-art sdAb solutions will bring unmatched comfort to your projects. Please feel free to contact us and learn more about our immune sdAb library construction service.
Case Study
All services are provided for research purposes only. Our services cannot be used for clinical or therapeutic applications.
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