Creative Biolabs is a professional expert in providing comprehensive customized antibody-directed enzyme prodrug therapy (ADEPT) development services with the most suitable linkers for targeted immunotherapy. Based on advanced DrugLnk™ platform, we promise to design and generate the most appropriate linkers for your ADEPT project development.
ADEPT is one of the forms of antibody-drug conjugate (ADC). The linker technology profoundly affects the toxicity, stability and half-life, and ultimately the efficacy of the ADC. In ADEPT, the conjugation of antibody or antibody fragment is usually carried out by conventional linkers, including 2-mercapto-[S-acetyl]acetic acid, N-hydroxysuccinimide ester (SATA), and m-maleimidobenzoyl-N-hydroxysuccinimide ester (SMPB). However, previous research showed that some enzymes, such as CPG2, are relatively sensitive to modification. What’s more, insertion of three maleimide groups per CPG2 may result in the loss of enzyme activity to some degree. Therefore, to avoid the activity lost of enzyme, Creative Biolabs offers customized linkers for specific enzymes to achieve coupling without affecting enzyme activity.
Fig.1 Schematic structure of antibody links to payload (enzyme) via the linker.
ADEPT is progressively developed into an attractive therapy method for cancer treatment. The antibody component confers the agent with exquisite specificity for targeting both primary tumors and metastases. The enzyme component can be cytotoxic or, when localized, to activate a prodrug. What’s more, the linker part could facilitate the conjugation of enzyme to antibodies and in the meantime, dictate the release mechanism of an ADEPT.
Fig.2 Antibody-directed enzyme prodrug therapy. A staged system of cancer therapy. (Andrady, 2011)
Creative Biolabs is dedicated to helping you develop novel ADEPT with optimized linkers for different enzymes in a timely and cost-effective manner. Our high-quality services and products will contribute greatly to the success of your projects. We also provide other various services regarding ADEPT development. Please feel free to contact us for more information.
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