Antibody-drug conjugates (ADCs) are innovative next-generation immune therapy agents that combine the specific targeting capacity of a monoclonal antibody with cytotoxic drugs. They are designed for accurate drug delivery to minimize collateral damages to healthy tissues. With the antibody Fc region that triggers antibody dependent cellular cytotoxicity (ADCC) or complement dependent cytotoxicity (CDC) and the cytotoxicity of the payload drug, some ADCs exert a “two-fold” killing efficacy towards targeted cancer cells. Due to their unique nature, ADC in vivo evaluation is of crucial importance since this process provides information regarding their efficacy and safety, which serves as a prerequisite and a guideline for clinical trial design. As a well-recognized leader in ADC preparation and with over a decade of experience, Creative Biolabs is dedicated for the development of new therapeutic agents and we offer our clients with comprehensive high-quality services for ADC in vivo evaluation.
Creative Biolabs employs a variety of animals, including rodents, canine, or non-human primates, for the assessment of the in vivo pharmacokinetic properties, ADME pattern, efficacy, potential immunogenicity, and safety of an ADC.
Creative Biolabs is equipped with outstanding animal facilities where all test animals are maintained in a clean and feed-enriched environment. All in vivo experiments are carried out following Institutional Animal Care and Use Committee (IACUC) approved protocols. With great devotion to our clients, Creative Biolabs offers highly customarily tailored in vivo ADC evaluation services and in vitro ADC analysis services to fit your timeline and research budget. Please contact us for more information and a detailed quote.
For Research Use Only. NOT FOR CLINICAL USE.
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