Antibody-Magnetic Ion Probes

Magnetic resonance imaging (MRI) is a medical imaging technique widely used to generate internal structure images of the body by using strong magnetic fields, radio waves, and field gradients. MRI is a highly versatile imaging technique with a wide range of biomedical applications, including high-resolution imagery and diagnosis of numerous diseases. Besides its extensive application in hospitals, as well as biomedical and clinical study centers, MRI is also a perfect technique to generate images of non-living objects, providing a detailed spatial map with numerous chemical and physical data. One MRI image is usually formed according to the relaxation time of water protons in the sample detected by the signal receiver. In some cases, MRI contrast agents are applied to improve the image quality. Contrast agents applied to the sample can shorten, or in certain cases increase, the relaxation time of nearby water protons in the sample, therefore resulting in the alteration of the image contrast.

Some metal ions, due to their paramagnetic/superparamagnetic properties, are good candidates as contrast agents of MRI for the diagnosis of certain diseases including cancer and a series of brain-related diseases. The magnetic-ion-based contrast agents are used to improve the internal body structure elucidation in clinical application of MRI. Generally used MRI contrast agents include the paramagnetic Gadolinium (Gd), Manganese (Mn), as well as the superparamagnetic Iron (Fe) oxide and Iron Platinum (Pt). In most applications, these metal ions are usually immobilized by other compounds such as chelating agents, to reduce their toxicity (metal ions can cause protein denaturing in vivo). The chelated magnetic ion complexes enable their further conjugation with functional bio-materials, including antibodies, which results in the antibody-magnetic ion probes that can enhance the contrast for the imaging of certain tissues/organs in the body presenting the targeted antigens and result in more efficient diagnosis of specific diseases.

A. The chemical structure of the chelating agent DOTA (chelator). B. The chemical structure of gadoteric acid which is a Gd-based MRI contrast agent consisting of DOTA as the chelator and G(III). C. Examples of T1-weighted (a), T2-weighted (b), and proton density (PD)-weighted (c) MRI scans (<em>Sci. Rep.</em>, 2015). A. The chemical structure of the chelating agent DOTA (chelator). B. The chemical structure of gadoteric acid which is a Gd-based MRI contrast agent consisting of DOTA as the chelator and G(III). C. Examples of T1-weighted (a), T2-weighted (b), and proton density (PD)-weighted (c) MRI scans (Sci. Rep., 2015).

Besides the application as contrast agents for high-resolution imagery via diverse MRI techniques, the antibody-magnetic ion probes can also be exploited for other applications in biomedical studies, including separation of biomaterials, e.g., cell-, DNA-, protein-sorting, and RNA fishing, as well as the treatment of cancer and other diseases, such as targeted drug delivery, magnetic hyperthermia, and magnetofection.

With over a decade’s experiences in conjugation chemistry and high-resolution imagery, the science team at Creative Biolabs provides customs with antibody-magnetic ion probes with high purity and excellent performance. With a large antibody-library and the expertise in developing custom antibody-based products, Creative Biolabs is dedicated to be you one-stop-shop for customized antibody-magnetic ion probes. Please contact us for more information and a detailed quote.

References

  1. Yu, M. K.; et al. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics, 2012, 2: 3-44.
  2. Uchiyama, M. K.; et al. Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool. Int. J. Nanomedicine, 2015, 10: 4731-4746.
  3. Sarracanie, M.; et al. Low-cost high-performance MRI. Sci. Rep., 2015, 5: 15177.


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