The design of linkers and release strategy of antibody-antibiotic conjugate (AAC) essentially follows the same principles as that of antibody-drug conjugate (ADC)- suitable structure must be chosen to achieve a well-balanced combination of drug efficacy, safety, circulation stability, target selectivity and cost. Despite the great progress in linker design over the past decade, several major challenges remain. Among the critical concerns is the fact that antibodies have half-lives of multiple days, therefore a linker is preferred to possess similar stability at physiologically relevant pH so as to prevent pre-mature drug release. In addition, attachment of linker and antibiotic agent to the antibody should have little adverse effect on the biological properties and stability of the antibody. With a deep understanding of important role in the AAC development and years of experience in compound synthesis, Creative Biolabs promise to deliver the most appropriate linker for your project.
Types of Linkers
As a result of the involvement of complex chemical and biological aspects in linker development, only a limited number of linker types are used in existing ADCs, including thioether, peptide, disulfide and hydrazine. In theory, these linkers exhibit different release mechanisms and thus allowing for a variety of conjugation strategies. According to the drug release mechanism, linkers are generally categorized either as cleavable linkers that are prone to chemical or enzymatic cleavage, or as non-cleavable linkers where drug is released upon the degradation of antibody.
Our Strength
Inspired by the successful examples of chemical linker in previous ADC development, Creative Biolabs has built the “DrugLnk” service platform - a special technical service platform based on our comprehensive understandings of the drug and linker chemistry. “DrugLnk” is tailored into two interactive modules-the drug module and the linker module that both contribute to the drug-linker “warhead” assembly. To accommodate the diverse needs of our worldwide clients, we are proud to offer a large selection of known linkers for regular applications, as well as our featured custom linker services for your specific requirement.
The “DrugLnk” linker module is designated for linker design and we offer the preparation of different linker based on their drug release mechanisms:
Relying on the advanced synthetic chemistry platform and a large arsenal of in-house antibiotics, linkers, and drug-linker sets products at Creative Biolabs, in “DrugLnk” our experienced chemists will help clients to:
Creative Biolabs is dedicated to providing quality services and products to promote the progress of AAC linker discovery and development. Our team of skilled scientists work closely with the clients to meet their project objectives and requirements. For more information about our AAC linker service, please contact us for more information and a detailed quote.
For Research Use Only. NOT FOR CLINICAL USE.
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