Category:
Non-Human Primate (NHP) related Antibody Products
Bax Monoclonal Antibody (DO-9) (NHP-AB171)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing mouse against human Bax peptide (a.a. 3-16). It is used only in in vitro assays.
Introduction:
BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Conjugate:
None
Antibody Isotype:
IgG1
Applications:
Flow Cytometry
Host Species:
Mouse
Species Reactivity:
Bovine; Human; Monkey
Immunogen:
Human Bax peptide (a.a. 3-16)
Format:
Liquid
Concentration:
0.1 mg/mL
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Storage:
Store at 4⁰C.
Target:
Bax
Clone:
DO-9
Clonality:
Monoclonal
Alternative Names:
Apoptosis regulator BAX; Bax zeta; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; Bcl2-L-4
Entrez Gene ID:
581
- Bax Monoclonal Antibody (DO-9) (NHP-AB171) Data Sheet: Detailed information. datasheet
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