Bax Monoclonal Antibody (Y6R3) (NHP-AB172)

• This product is an antibody that was generated by immunizing mouse against bax peptide (a.a. 12-24) common to mouse, rat, and human. It is used only in in vitro assays.

Detailed Product Description

• Introduction: BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
• Conjugate: None
• Antibody Isotype: IgG1
• Applications: Flow Cytometry

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Bovine; Human; Monkey; Mouse; Rat
• Immunogen: Bax peptide (a.a. 12-24) common to mouse, rat, and human

Product Property

• Format: Liquid
• Concentration: 0.1 mg/mL
• Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
• Storage: Store at 4⁰C.

Target Information

• Target: Bax
• Clone: Y6R3
• Clonality: Monoclonal
• Alternative Names: Apoptosis regulator BAX; Bax zeta; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; Bcl2-L-4
• Entrez Gene ID: 581/12028/24887