Category:
Non-Human Primate (NHP) related Antibody Products
CCR4 Polyclonal Antibody (NHP-AB321)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a peptide located in the 2nd extracellular domain of CCR4 (Human). It is used only in in vitro assays.
Introduction
CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
Conjugate
None
Applications
ELISA; IHC
Host Species
Rabbit
Species Reactivity
Gibbon; Gorilla; Human; Monkey
Immunogen
A peptide located in the 2nd extracellular domain of CCR4 (Human)
Purification
Immunoaffinity Chromatography
Format
Liquid
Concentration
1 mg/mL
Buffer
PBS, 0.1% sodium azide.
Storage
Short term: 4˚C. Long term: Store at -20˚C.
Clonality
Polyclonal
Alternative Names
C-C chemokine receptor type 4; C-C CKR-4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; fusin; K5-5; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293
Entrez Gene ID
1233
- CCR4 Polyclonal Antibody (NHP-AB321) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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