Category:
Non-Human Primate (NHP) related Antibody Products
CD79a Recombinant Antibody (R4LA) (NHP-AB502)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is a recombinant antibody recognizing CD79a. It is used only in in vitro assays.
Introduction:
CD79a is a disulphide-linked heterodimer that includes B29 (CD79b) polypeptide. CD79a is a B lymphocyte antigen receptor with an antigen-specific surface component Ig (immunoglobulin) that associates with Ig-alpha and Ig-beta, necessary elements for the expression and function of the B-cell antigen receptor. CD79a first appears at pre-B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines.
Conjugate:
None
Antibody Isotype:
IgGk
Applications:
IHC-P; WB
Host Species:
Rabbit
Species Reactivity:
Bovine; Human; Monkey; Mouse; Pig; Rat
Immunogen:
Amino acids 202-216 (GTYQDVGSLNIADVQ)
Purification:
Protein A Affinity Chromatography
Format:
Liquid
Concentration:
0.2 mg/mL
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Storage:
Store at 4⁰C. Avoid freeze-thaw cycles.
Clone:
R4LA
Clonality:
Monoclonal
Related Disease:
Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.
Alternative Names:
CD79A, Ig-alpha, IGA; Igalpha; Ly-54; Ly54; MB-1; MB1
Entrez Gene ID:
973
Function:
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
- CD79a Recombinant Antibody (R4LA) (NHP-AB502) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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