Category:
Non-Human Primate (NHP) related Antibody Products
GFAP Polyclonal Antibody (NHP-AB351)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
FAQs
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against GFAP isolated from cow spinal cord. It is used only in in vitro assays.
Introduction:
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Conjugate:
None
Antibody Isotype:
IgG
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Bovine; Chicken; Guinea Pig; Hamster; Human; Monkey; Mouse; Rat; Sheep
Immunogen:
GFAP isolated from cow spinal cord
Purification:
Purified
Format:
Liquid
Buffer:
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
Storage:
Short term: 4˚C. Long term: Store at -20˚C.
Clonality:
Polyclonal
Alternative Names:
FLJ45472; GFAP; GFAP epsilon; Glial fibrillary acidic protein; glial fibrillary acidic protein alpha; intermediate filament
Entrez Gene ID:
2670
- GFAP Polyclonal Antibody (NHP-AB351) Data Sheet: Detailed information. datasheet
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Q 1: What makes GFAP Polyclonal Antibody unique in research applications?
A: GFAP Antibody's high specificity and broad species reactivity make it invaluable for studying astrocyte behavior and neural diseases across diverse models.
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Q 2: Can GFAP Polyclonal Antibody be used in both Western Blot and Immunocytochemistry?
A: Yes, it's designed for multiple applications, ensuring versatility in detecting astrocyte presence and functionality in various tissues and conditions.
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Precisely and Quantify
GFAP polyclonal antibody from Creative Biolabs played a very useful role in my recent study of ischemic brain injury as a neurodegeneration researcher. It has allowed us to recognize precisely and quantify lost neurons while expressing the other two significant markers in ischemia: reactive gliosis and cell proliferation. That has been very helpful in getting a detailed insight into the neuronal dynamics, especially at the level of hippocampus. This product, along with its NHP Method Development & Validation service, has pushed our research to new bounds and has given new ways to understand and treat neurological conditions.
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Your research is unique, and we understand that standard products may not always fit. Our team of experts specializes in custom NHP sample collections. We can design a tailored protocol to meet your specific research requirements, including samples with unique anticoagulant types, customized volumes, or from specific disease models.
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For research use only. Not intended for any clinical use.
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