SAFB Monoclonal Antibody (H9U3) (NHP-AB246)

• This product is an antibody that was generated by immunizing mouse against amino acids 345 - 357 of SAFB (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
• Conjugate: None
• Antibody Isotype: IgG1
• Applications: IF; IHC; IP; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Gibbon; Gorilla; Human; Monkey; Orangutan
• Immunogen: Amino acids 345 - 357 of SAFB (Human)

Product Property

• Purification: Protein G purified from tissue culture supernatant
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS
• Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target Information

• Clone: H9U3
• Clonality: Monoclonal
• Alternative Names: DKFZp779C1727; glutathione S-transferase fusion protein; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein; Hsp27 ERE-TATA binding protein; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF-B; Scaffold attachment factor B1
• Entrez Gene ID: 6294