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CD123

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Product List

Here are the products related to CD123 CAR, so you can choose the one that will be useful for your research project!

Background

IL-3 is a pleiotropic interleukin cytokine produced primarily by activated T lymphocytes. It mainly regulates the function and production of hematopoietic cells and immune cells. The IL-3 receptor (IL-3R) is a heterodimer composed of α and β chains, and CD123 is the α chain of the interleukin 3 receptor (IL-3Rα). Studies have shown that CD123 is overexpressed on a variety of tumor cells and plays a role in promoting the excessive proliferation of tumor cells. As a result, CD123 has emerged as an attractive novel therapeutic target for hematological malignancies.

Fig.1 Schematic diagram of the structure of CD123. (El Achi, et al., 2020) Fig.1 Schematic diagram of the structure of CD123.1

Associated Diseases

Plasmacytoid Dendritic Cell Tumor

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia/Lymphoma

Hairy Cell Leukemia

Systemic Mastocytosis

Anti-CD123 CAR-T Services

CD123 CAR Design & Construction

With an advanced technology platform and strong scientific research strength, Creative Biolabs constructs effective and stable CD123 CAR-T cells for you through CAR molecular structure design, T-cell transfection, CAR-T cell identification, etc.

Fig.2 Schematic diagram of CD123 CAR construction. (Sugita, et al., 2022)Fig.2 Schematic diagram of CD123 CAR construction.2

Anti-CD123 CAR-T In Vitro Assays

Anti-CD123 CAR-T Cytokine Release Test

Cytokine Release Syndrome (CRS) can cause microvascular system damage, and cytokines such as IFN-γ and IL-6 are released in large quantities, which can promote each other with the coagulation activation process, and finally form multi-organ failure. There are many cytokines associated with CRS, but a few are particularly critical, namely IL-2, IFN-γ, IL-6, and IL-10.

Fig.3 IFN-γ levels of CD123 CAR-T in the supernatant after cell co-culture. (Sugita, et al., 2022)Fig.3 IFN-γ levels of CD123 CAR-T in the supernatant after cell co-culture.2

Anti-CD123 CAR-T In Vitro Cytotoxicity Assay

Creative Biolabs offers cytotoxicity assays to measure the cancer cell-killing capacity of effector cells. The four most commonly used assays are chromium (51 chromium) release assays, luciferase-mediated bioluminescence imaging assays, impedance-based assays, and flow cytometry assays.

Fig.4 Assessment of the CD123 CAR-T cytotoxicity. (Sugita, et al., 2022) Fig.4 Assessment of the CD123 CAR-T cytotoxicity. The results showed a significant reduction in CD123 CAR-T-induced CB cell death.2

Anti-CD123 CAR-T In Vivo Assays

Anti-CD123 CAR-T Cell Therapy Animal Models

Due to species differences, there are problems such as species specificity of CAR-T cells and tumor targets, xenograft-versus-host responses, and difficulties in mimicking human immune responses in animals, and the selection of appropriate animal models is crucial for the proof of concept of CAR-T cell function. Creative Biolabs offers humanized mouse models to help you test information about the efficacy, distribution, and proliferation characteristics of CAR-T cells in vivo.

Fig.5 In vivo study of CD123 CAR-T in NSG mice. (Sugita, et al., 2022)Fig.5 In vivo study of CD123 CAR-T in NSG mice.2

Efficacy Test of Anti-CD123 CAR-T

In vivo efficacy assessment is essential to study the factors that influence the efficacy of CAR-T. Creative Biolabs offers a range of in vivo pharmacodynamic evaluation services for CD123 CAR-T to provide a scientific basis for your preclinical studies.

Fig.6 Efficacy of CD123 CAR-T treated NSG mice. (Sugita, et al., 2022)Fig.6 Efficacy of CD123 CAR-T treated NSG mice. The results showed that CD123 CAR-T effectively eliminated leukemia.2

Viability Study of Anti-CD123 CAR-T

Creative Biolabs offers a range of CD123 CAR-T viability study services, including but not limited to in vivo proliferation and survival assays, T cell migration and distribution, memory T cell responses, and more.

Fig.7 Survival curves of CD123 CAR-T treated with PDX-AML2. (Sugita, et al., 2022) Fig.7 Survival curves of CD123 CAR-T treated with PDX-AML2. The results showed that CD123 CAR-T treatment significantly prolonged the overall survival of PDX-AML2.2

References

  1. El Achi, Hanadi.; et al. "CD123 as a biomarker in hematolymphoid malignancies: Principles of detection and targeted therapies." Cancers. (2020) 12,11 3087.
  2. Sugita, M.; et al. "Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia." Nat Commun. (2022) 13, 2227.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-0323-LX448 Anti-CD123 VHH(X3XH79) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH79 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX449 Anti-CD123 VHH(X3XH80) h(ICOS-41BB-CD3ζ) CAR, pCDCAR1 Vector Human X3XH80 VHH-ICOS-4-1BB-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX805 Anti-CD123 VHH(X3XH67) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH67 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX806 Anti-CD123 VHH(X3XH68) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH68 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX807 Anti-CD123 VHH(X3XH69) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH69 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX808 Anti-CD123 VHH(X3XH70) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH70 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX809 Anti-CD123 VHH(X3XH71) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH71 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX810 Anti-CD123 VHH(X3XH72) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH72 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX811 Anti-CD123 VHH(X3XH73) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH73 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX812 Anti-CD123 VHH(X3XH74) h(CD28-OX40-CD3ζ) CAR, pCDCAR1 Vector Human X3XH74 VHH-CD28-OX40-CD3ζ Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX3814 TRAC-CD123 (X3XT16) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT16 Mouse Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX3815 TRAC-CD123 (X3XT17) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT17 Mouse Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX3816 TRAC-CD123 (X3XT18) h(CD28-41BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT18 Mouse Homology arm-EF1a-scFv-CD28-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4056 TRAC-CD123 (X3XT16) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector Human X3XT16 Mouse Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4057 TRAC-CD123 (X3XT17) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector Human X3XT17 Mouse Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4058 TRAC-CD123 (X3XT18) h(CD28-OX40-CD3ζ) replaced CAR, pcDNA Vector Human X3XT18 Mouse Homology arm-EF1a-scFv-CD28-OX40-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4298 TRAC-CD123 (X3XT16) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT16 Mouse Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4299 TRAC-CD123 (X3XT17) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT17 Mouse Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0323-LX4300 TRAC-CD123 (X3XT18) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector Human X3XT18 Mouse Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm Nonviral T cell CAR-T   Add to Cart   Datasheet
XS-0823-LX9 Anti-hCD123 (G3) ICD(CD28-OX40-CD3ζ) CAR-MA, pAd5f35 Vector Human G3 Adenoviral vectors   Add to Cart   Datasheet
XS-0923-LX69 Anti-hCD123 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector Human X9X-38 scFv-CD28-41BB-CD3ζ-duplex CTLA4 Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
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