Anti-Membrane Protein Antibody Discovery Using Speed™ Mouse

Creative Biolabs is committed to providing world-leading, custom-oriented services to promote the progress of diverse antibody projects. Equipped with high-end technology platforms as well as significant knowledge in this field, we are now confident to present our professional anti-membrane protein antibody development service using unique Speed™ mouse.

Membrane proteins play a fundamental role in many cellular biophysical functions. Although membrane proteins only make up ~23% of entire human proteome, they constitute more than 60% of current drug targets, like GPCRs, ion channels, transporters, etc. Anti-membrane protein antibodies have been actively exploited and they are gaining a significant amount of attention during the recent years. However, as is known, membrane proteins manifest as a very challenging class of antigens due to their complicated structure, hydrophobic transmembrane domains, difficulties in expression and stabilization, etc. Multiple routes have been explored in this regard, such as soluble peptide surrogate, liposomes, nanodiscs, lipoparticles, DNA immunization, etc. In most cases, sufficient immune response is the most critical step, especially for weak antigens.

However, in terms of immunization process, membrane proteins sometimes appear as weak immunogens and fail to elicit strong immune response because of their complicated structures or high homology with immune hosts. Meanwhile, it typically takes several months to generate enough IgGs. These technical problems and lacking experiences hamper the progress of many anti-membrane protein antibody discovery projects. To get rid of the situation, Creative Biolabs brings series of leading antibody development services with our Speed™ mouse. The Speed™ mouse stain enables rapid immunization as short as 20 days against challenging targets and thus being more efficient for anti-membrane protein antibody discovery.

Significant highlights of the Speed™ Anti-Membrane Protein Antibody Development Platform

Anti-Membrane Protein Antibody Discovery Using Speed™ Mouse

Fast immunization: the Speed™ mouse strain enables adequate immune responses with high IgG secretion in less than 20 days, while the traditional BALB/c mouse takes several months. This will benefit the urgent projects or highly competitive cases.
High sensitivity: the sensitive immune system have the capability to generate potent immune response even for low-immunogenicity immunogens and high homologous targets.
Versatile technologies: we incorporate this specialty mouse resource with multiple powerful anti-membrane protein antibody discovery strategies (i.e. hybridomas, phage display, B cell sorting), providing flexible choices according to your specific requirements.
Multiple immunogen choices: with extensive experience and dedicated efforts, Creative Biolabs has established a powerful membrane protein immunogen preparation platform. Many functional GPCR immunogens, ion channel immunogens, and transporter immunogens have been successfully designed and obtained for immunization or selection.
Competitive price

Creative Biolabs is professional in tailoring high specific, high-affinity antibodies targeting various membrane proteins (GPCRs/ Transporters/ Ion channels). We offer one-stop services from immunogen preparation to antibody production. Based on our excellent cell-based and cell-free expression systems, we could prepare membrane protein in various immunogen formats (e.g. exosomes, polymers, virus-like particles) to fulfill your needs. Please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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