ADCs Toxins, Herboxidiene is described as a microbial product with antitumor activity. Herboxidiene seems to serve as a novel splicing inhibitor that specifically impairs the SF3b function by binding to SAP155. Herboxidiene in house activity data obtained from our manufacturing partner: Cellular line A549 (lung cander) IC50: 0,036 ug/ml - IC50 82 uM; Cellular line H116 (colon cancer) IC50 0,01 ug/ml - IC50 22,7 uM; Cellular line PSN1 (pancreatic cancer) IC50 0,036 ug/ml - IC50 82 uM - Cellular line T98G (glioblastoma) IC50 1 ug/ml - IC50 20,5 mM
- Description
- ADCs Toxins, Herboxidiene is described as a microbial product with antitumor activity. Herboxidiene seems to serve as a novel splicing inhibitor that specifically impairs the SF3b function by binding to SAP155. Herboxidiene in house activity data obtained from our manufacturing partner: Cellular line A549 (lung cander) IC50: 0,036 ug/ml - IC50 82 uM; Cellular line H116 (colon cancer) IC50 0,01 ug/ml - IC50 22,7 uM; Cellular line PSN1 (pancreatic cancer) IC50 0,036 ug/ml - IC50 82 uM - Cellular line T98G (glioblastoma) IC50 1 ug/ml - IC50 20,5 mM
- Classification
- RNA Inhibitors
For Research Use Only. NOT FOR CLINICAL USE.
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