CSF2RA

Colony stimulating factor 2 receptor alpha subunit (CSF2RA), also known as CD116 or GM-CSF-R-alpha, is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which regulates the formation, differentiation, and function of granulocytes and macrophages. CSF2RA is a member of the cytokine family of receptors and the gene encoded which is identified in the pseudoautosomal region (PAR) of the X and Y chromosomes. Besides, it is primarily a ligand-binding subunit, contains a short 54 amino acid intracellular domain, which offers specificity of signaling.
CSF2RA, together with CSF2RB, are two receptor subunits for GM-CSF. Former research has demonstrated that GM-CSF signaling is inhibitory to leukemogenesis in a murine model for acute myeloid leukemia (AML), and aids in increasing myeloid differentiation of leukemic blasts. Importantly, about 32-59% of AML patients suffer from haploinsufficiency of CSF2RA. Moreover, the CSF2RA expression has also been shown to be lower in AML patients compared to other patients. Researchers have also considered that CSF2RA may be a tumor suppressor. Additionally, CSF2RA is expressed on several cancer cells, including cervical cancer, head and neck cancer and testis cancer.
Gene ID: 1438
UniProt ID: P15509