IGF2

Insulin like growth factor 2 (IGF2), also called GRDF or C11orf43, is a member of the insulin family (IGF) of polypeptide growth factors, which are associated with development and growth. The IGF family composed of three ligands (IGFI, IGF2, and insulin), at least six binding proteins (IGFBP-1 to -6), as well as three specific cell surface receptors which regulate the actions of the ligands (IGFI receptor, insulin receptor (IR), and the IGF2 mannose-6-phosphate). IGF2 is a peptide of 67 amino acids and shares about 50% amino acid homology to insulin. The IGF2 gene in human is located on the short arm of chromosome 11, which is an imprinted gene with paternal allele expressed and maternal allele silenced.
To date, the most important role of IGF2 is as a growth enhancing hormone during gestation. IGF2 functions through binding to the IGF-1 receptor and to the short isoform of the insulin receptor. It also serves an essential role in signalling antagonist by binding to the IGF2 receptor (the cation-independent mannose 6-phosphate receptor).
Gene ID: 3481
UniProt ID: P01344