Beta-glucans Blocker (ES-0526-YC222)

Product Overview

In quality control and pharmaceutical safety testing, the accuracy of bacterial endotoxin detection is paramount. However, conventional Limulus Amebocyte Lysate (LAL) reagents are inherently bi-specific. They react not only to gram-negative bacterial endotoxins but also to (1,3)-beta-D-glucans that is polysaccharides found in fungal cell walls, cellulosic filters and plant-derived excipients. This dual-sensitivity routinely introduces false-positive results, falsely inflating endotoxin measurements and risking costly, unnecessary batch rejections.
Creative Biolabs' Beta-Glucan Blocker is a specialized reconstitution solution designed to eliminate this interference. By directly substituting standard LAL Reagent Water (LRW) during the reconstitution of Lyophilized Amebocyte Lysate, our formulation completely saturates and inhibits the carbohydrate-reactive cascade. This mechanism guarantees that your LAL assay remains exclusively sensitive to gram-negative bacterial endotoxins, safeguarding your data integrity and streamlining regulatory compliance.

Applications

For blocking β-glucan interference in LAL assay.

Endotoxin Level

< 0.005 EU/mL

Size

10 mL

Package

10 vials

Storage

Store at 4°C.