Category:
Non-Human Primate (NHP) related Antibody Products
ACTA2 Polyclonal Antibody (NHP-AB256)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
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Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a synthetic peptide from N-Terminus of human alpha smooth muscle. It is used only in in vitro assays.
Introduction:
ACTA2, also known as smooth muscle actin, belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle. Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands. Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6. Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. Multiple alternatively spliced variants of smooth muscle actin have been identified.
Conjugate:
None
Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Baboon; Bovine; Chicken; Human; Mouse; Rabbit; Rat
Immunogen:
A synthetic peptide from N-Terminus of human alpha smooth muscle
Purification:
Immunoaffinity Chromatography
Format:
Liquid
Buffer:
10 mM PBS, pH 7.4, BSA, sodium azide.
Storage:
Store at 4⁰C. Avoid freezing.
Clonality:
Polyclonal
Alternative Names:
actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; Alpha-actin-2; alpha-cardiac actin; Cell growth-inhibiting gene 46 protein; smooth muscle; smooth muscle alpha-actin
Entrez Gene ID:
59
- ACTA2 Polyclonal Antibody (NHP-AB256) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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