ACVR1 Polyclonal Antibody (NHP-AB294)

• This product is an antibody that was generated by immunizing rabbit against a synthetic peptide corresponding to amino acids 496-509 (TKIDNSLDKLKTDC) of amino acids 475-525 of human ACVR1, GenBank NP 001096. It is used only in in vitro assays.

Detailed Product Description

• Introduction: The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
• Conjugate: None
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bat; Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat; Xenopus
• Immunogen: A synthetic peptide corresponding to amino acids 496-509 (TKIDNSLDKLKTDC) of amino acids 475-525 of human ACVR1, GenBank NP 001096

Product Property

• Purification: Protein G Column
• Format: Liquid
• Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: activin A receptor type I; activin A receptor, type 1; activin A receptor, type I; activin A receptor, type II-like kinase 2; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; hydroxyalkyl-protein kinase; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; TSR-I
• Entrez Gene ID: 90