Category:
Non-Human Primate (NHP) related Antibody Products
ARHGEF11 Polyclonal Antibody (NHP-AB305)
Product Overview
Detailed Product Description
Technical Specifications
Product Property
Target Information
Downloadable Resources
Customer Reviews
This product is an antibody that was generated by immunizing rabbit against a portion of amino acids 1-50 of human ARHGEF11. It is used only in in vitro assays.
Introduction:
ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
Conjugate:
None
Applications:
IHC; WB
Host Species:
Rabbit
Species Reactivity:
Bovine; Chicken; Chimpanzee; Dog; Horse; Human; Monkey; Mouse; Rat
Immunogen:
A portion of amino acids 1-50 of human ARHGEF11.
Purification:
Affinity purification
Format:
Liquid
Concentration:
0.5 mg/mL
Buffer:
PBS, 0.2% gelatin, 0.05% sodium azide.
Storage:
Store at -20⁰C. Avoid freeze-thaw cycles.
Clonality:
Polyclonal
Alternative Names:
glutamate transporter EAAT4-associated protein 48; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; RP11-356J7.2
Entrez Gene ID:
9826
- ARHGEF11 Polyclonal Antibody (NHP-AB305) Data Sheet: Detailed information. datasheet
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For research use only. Not intended for any clinical use.
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